170552

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3244176..3244590 Replicon chromosome
Accession NZ_CP060666
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag H9Q88_RS16125 Protein ID WP_000994230.1
Coordinates 3244333..3244590 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3244176..3244508 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q88_RS16085 3239437..3239934 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
H9Q88_RS16090 3240697..3241267 - 571 Protein_3143 integrase core domain-containing protein -
H9Q88_RS16095 3241188..3241397 - 210 WP_001676010.1 hypothetical protein -
H9Q88_RS16100 3241450..3241764 + 315 WP_072100769.1 SymE family type I addiction module toxin -
H9Q88_RS16105 3241831..3242109 - 279 WP_012543321.1 hypothetical protein -
H9Q88_RS16110 3242426..3242893 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
H9Q88_RS16115 3242890..3243207 - 318 WP_001751277.1 hypothetical protein -
H9Q88_RS16120 3243765..3243998 - 234 WP_124084119.1 hypothetical protein -
- 3244176..3244508 - 333 - - Antitoxin
H9Q88_RS16125 3244333..3244590 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
H9Q88_RS16130 3244656..3245102 - 447 WP_000171102.1 hypothetical protein -
H9Q88_RS16135 3245099..3248473 - 3375 Protein_3152 RHS domain-containing protein -
H9Q88_RS16140 3248473..3248979 - 507 Protein_3153 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3233868..3244590 10722
flank IS/Tn - - 3240697..3240975 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T170552 WP_000994230.1 NZ_CP060666:3244333-3244590 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T170552 NZ_CP077638:c4551-4147 [Methylorubrum extorquens]
ATGTTCGTAGACGCGTCGGCGATCATCGCGATCATCGCACGCGAGCCGCAGGCGGAAACATTGACGGCCCGGCTCGAGGA
GGCGCCCGTCCGCTATACCTCGGCAGTGGCCGTCTTGGAAACGGTGATGGCCTTGCGGCGCCTCGGTGCGGGATCGATCG
CGCAAGCAGAGCAACTGGTGCGACATCTGCTCGAGCATGCGGATATTGAGGAAGTCCCCATCACAACGCGGGAGTCGGCT
GCGGCCATCGCCGCATACGCGCGCTACGGCAAAGGCCAGGGCCACCCTGCCCAACTCAACCTCGGCGACTGCTTCGCCTA
TGCCTGCGCTCGAACGCGCAACGTCCCGCTTCTCTTCGTCGGCAACGACTTCTCGCAGACCGACATCGCCGCTGCATTGG
CCTGA

Antitoxin


Download         Length: 333 bp

>AT170552 NZ_CP060666:c3244508-3244176 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References