37257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3736469..3736901 Replicon chromosome
Accession NZ_AP023291
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain L-4126

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag K5613_RS18465 Protein ID WP_000994224.1
Coordinates 3736626..3736901 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3736469..3736891 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5613_RS18435 3732687..3733424 - 738 WP_001535430.1 pili assembly chaperone SafB -
K5613_RS18440 3733508..3734020 - 513 WP_077248260.1 pilus assembly protein -
K5613_RS18445 3734770..3735474 - 705 Protein_3625 integrase core domain-containing protein -
K5613_RS18450 3735527..3735775 + 249 WP_001738030.1 SymE family type I addiction module toxin -
K5613_RS18455 3735877..3736185 - 309 WP_010988969.1 hypothetical protein -
K5613_RS24390 3736268..3736441 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3736469..3736891 - 423 - - Antitoxin
K5613_RS18465 3736626..3736901 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
K5613_RS18470 3736954..3737391 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
K5613_RS18475 3737954..3738400 - 447 WP_000935097.1 protein SciX -
K5613_RS18480 3738394..3739263 - 870 Protein_3632 polymorphic toxin type 47 domain-containing protein -
K5613_RS18485 3739327..3739590 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3725617..3739590 13973
flank IS/Tn - - 3734770..3735051 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T37257 WP_000994224.1 NZ_AP023291:3736626-3736901 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T37257 NZ_AP023291:3736626-3736901 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT37257 NZ_AP023291:c3736891-3736469 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References