221672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 773846..774260 Replicon chromosome
Accession NZ_CP085806
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF46_RS03570 Protein ID WP_000994230.1
Coordinates 773846..774103 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 773928..774260 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF46_RS03555 769457..769963 + 507 Protein_680 phage late control D family protein -
LJF46_RS03560 769963..773337 + 3375 Protein_681 RHS domain-containing protein -
LJF46_RS03565 773334..773780 + 447 WP_000171102.1 hypothetical protein -
LJF46_RS03570 773846..774103 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 773928..774260 + 333 - - Antitoxin
LJF46_RS03575 774438..774671 + 234 WP_124084119.1 hypothetical protein -
LJF46_RS03580 775229..775546 + 318 WP_001751277.1 hypothetical protein -
LJF46_RS03585 775543..776010 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF46_RS03590 776327..776605 + 279 WP_012543321.1 hypothetical protein -
LJF46_RS03595 776672..776986 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF46_RS03600 777039..777248 + 210 WP_001676010.1 hypothetical protein -
LJF46_RS03605 777169..777739 + 571 Protein_690 integrase core domain-containing protein -
LJF46_RS03610 778502..778999 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 768542..787633 19091
flank IS/Tn - - 777461..777739 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-56)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221672 WP_000994230.1 NZ_CP085806:c774103-773846 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221672 NZ_CP117563:c40837-40550 [Escherichia albertii]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAGCAACAGTTCGC
AAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGTGAACTAAAAAATTGCTACAAAATCA
AACTTCGTGCATCGGGTTTTCGTCTGGTCTATCAGGTTATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTTGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 333 bp

>AT221672 NZ_CP085806:773928-774260 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCCGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A656IER2


Antitoxin

Download structure file

References