Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3718262..3718694 Replicon chromosome
Accession NZ_CP117244
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag PQQ30_RS18365 Protein ID WP_000994224.1
Coordinates 3718419..3718694 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3718262..3718684 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ30_RS18335 3714480..3715217 - 738 WP_001535430.1 pili assembly chaperone SafB -
PQQ30_RS18340 3715301..3715813 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
PQQ30_RS18345 3716563..3717267 - 705 Protein_3588 integrase core domain-containing protein -
PQQ30_RS18350 3717320..3717568 + 249 WP_001738030.1 SymE family type I addiction module toxin -
PQQ30_RS18355 3717670..3717978 - 309 WP_010988969.1 hypothetical protein -
PQQ30_RS18360 3718061..3718177 - 117 WP_227457392.1 hypothetical protein -
- 3718262..3718684 - 423 - - Antitoxin
PQQ30_RS18365 3718419..3718694 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
PQQ30_RS18370 3718747..3719184 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
PQQ30_RS18375 3719747..3720193 - 447 WP_000935097.1 protein SciX -
PQQ30_RS18380 3720187..3721056 - 870 Protein_3595 polymorphic toxin type 47 domain-containing protein -
PQQ30_RS18385 3721120..3721383 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3707410..3721383 13973
flank IS/Tn - - 3716563..3716844 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T270179 WP_000994224.1 NZ_CP117244:3718419-3718694 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT270179 NZ_CP117244:c3718684-3718262 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References