146448

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3755945..3756377 Replicon chromosome
Accession NZ_CP047531
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10484

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN09_RS18650 Protein ID WP_000994224.1
Coordinates 3756102..3756377 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3755945..3756367 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN09_RS18620 3752163..3752900 - 738 WP_001535430.1 pili assembly chaperone SafB -
DXN09_RS18625 3752984..3753496 - 513 WP_077248260.1 pilus assembly protein -
DXN09_RS18630 3754246..3754950 - 705 Protein_3651 integrase core domain-containing protein -
DXN09_RS18635 3755003..3755251 + 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN09_RS18640 3755353..3755661 - 309 WP_010988969.1 hypothetical protein -
DXN09_RS18645 3755744..3755860 - 117 WP_227457392.1 hypothetical protein -
- 3755945..3756367 - 423 - - Antitoxin
DXN09_RS18650 3756102..3756377 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
DXN09_RS18655 3756430..3756867 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN09_RS18660 3757430..3757876 - 447 WP_000935097.1 protein SciX -
DXN09_RS18665 3757870..3758739 - 870 Protein_3658 polymorphic toxin type 47 domain-containing protein -
DXN09_RS18670 3758803..3759066 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3745093..3759066 13973
flank IS/Tn - - 3754246..3754527 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146448 WP_000994224.1 NZ_CP047531:3756102-3756377 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146448 NZ_CP062750:52835-53140 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 423 bp

>AT146448 NZ_CP047531:c3756367-3755945 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References