233726

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 994658..995090 Replicon chromosome
Accession NZ_CP091558
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag INN79_RS04705 Protein ID WP_000994224.1
Coordinates 994658..994933 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 994668..995090 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS04685 991969..992232 + 264 WP_000932531.1 hypothetical protein -
INN79_RS04690 992296..993165 + 870 Protein_909 polymorphic toxin type 47 domain-containing protein -
INN79_RS04695 993159..993605 + 447 WP_000935097.1 protein SciX -
INN79_RS04700 994168..994605 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
INN79_RS04705 994658..994933 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 994668..995090 + 423 - - Antitoxin
INN79_RS04710 995175..995291 + 117 WP_227457392.1 hypothetical protein -
INN79_RS04715 995374..995682 + 309 WP_010988969.1 hypothetical protein -
INN79_RS04720 995784..996032 - 249 WP_001738030.1 SymE family type I addiction module toxin -
INN79_RS04725 996085..996789 + 705 Protein_916 integrase core domain-containing protein -
INN79_RS04730 997539..998051 + 513 WP_077248260.1 pilus assembly protein -
INN79_RS04735 998135..998872 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 992392..1006680 14288
flank IS/Tn - - 996508..996789 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T233726 WP_000994224.1 NZ_CP091558:c994933-994658 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T233726 NZ_LN614827:252058-252699 [Legionella fallonii LLAP-10]
ATGACGTATTCACATTTAAACGCTGAAAAAGCATTGATTTGGCGTATAACTCATAAGGATAATATATCCGGCATTTTGGA
TAATGGTCTATATTGCGCTAATTCGCCTATTCAAATACCTTGTTATACACCTATTGGTAACATTGAATTAATTGGAAAGC
GAAAAAACCGGATAGTTTCACTCCATCCAGGGGGTACTTTGAGTGATTACATACCCTTTTATTTTACTCATTTTTCCCCA
ATGATGTATAACATACACACAGGTCGAGGGGTTAAACAATACCACAATAGTGAGCTGCTCATATTGGTGTCTAGTTTACG
CCTAGTTGAAGAAAATAACCTTGAGTTTTTATTTACTGATCGCCATGCTTATTTACAACGGGCGAATTATTATAATAATT
TAGATTCATTATCAGAAATTGATTGGTTGTCATTGCAGCAGCGTGATTTTAGGCTAAATCCCGAAGATCCTGAGAAATTT
GATCGCTATCAAGCTGAAGCTCTAATATATAATCATTTACCTATTAATAGTTTGAAAGGTATTGTTTGTTATACAGATGA
GCTAAAATTACAAATAGAGAATGAAATAGATATGCGGAATTTGTCGTTAACCGTTGTAACAAAACCAAGGTGGTATTTTT
AA

Antitoxin


Download         Length: 423 bp

>AT233726 NZ_CP091558:994668-995090 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References