Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
| Location | 3595672..3596086 | Replicon | chromosome |
| Accession | NZ_CP110220 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain MFDS1018147 | ||
Toxin (Protein)
| Gene name | IasE | Uniprot ID | M7RBD3 |
| Locus tag | OF824_RS17675 | Protein ID | WP_000994230.1 |
| Coordinates | 3595829..3596086 (+) | Length | 86 a.a. |
Antitoxin (RNA)
| Gene name | IsrA | ||
| Locus tag | - | ||
| Coordinates | 3595672..3596004 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OF824_RS17635 | 3590933..3591430 | - | 498 | WP_016695185.1 | Saf-pilin pilus formation protein | - |
| OF824_RS17640 | 3592193..3592763 | - | 571 | Protein_3448 | integrase core domain-containing protein | - |
| OF824_RS17645 | 3592684..3592893 | - | 210 | WP_001676010.1 | hypothetical protein | - |
| OF824_RS17650 | 3592946..3593260 | + | 315 | WP_072100769.1 | SymE family type I addiction module toxin | - |
| OF824_RS17655 | 3593327..3593605 | - | 279 | WP_012543321.1 | hypothetical protein | - |
| OF824_RS17660 | 3593922..3594389 | - | 468 | WP_000828182.1 | sugar tyrosine-protein kinase | - |
| OF824_RS17665 | 3594386..3594703 | - | 318 | WP_001751277.1 | hypothetical protein | - |
| OF824_RS17670 | 3595261..3595494 | - | 234 | WP_124084119.1 | hypothetical protein | - |
| - | 3595672..3596004 | - | 333 | - | - | Antitoxin |
| OF824_RS17675 | 3595829..3596086 | + | 258 | WP_000994230.1 | SymE family type I addiction module toxin | Toxin |
| OF824_RS17680 | 3596152..3596598 | - | 447 | WP_000171102.1 | hypothetical protein | - |
| OF824_RS17685 | 3596595..3599969 | - | 3375 | Protein_3457 | RHS domain-containing protein | - |
| OF824_RS17690 | 3599969..3600475 | - | 507 | Protein_3458 | phage late control D family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3584578..3599891 | 15313 | |
| flank | IS/Tn | - | - | 3592193..3592471 | 278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9490.94 Da Isoelectric Point: 9.5519
>T263444 WP_000994230.1 NZ_CP110220:3595829-3596086 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
Download Length: 258 bp
Antitoxin
Download Length: 333 bp
>AT263444 NZ_CP110220:c3596004-3595672 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
