146528

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3739728..3740160 Replicon chromosome
Accession NZ_CP047540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10359

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN31_RS18580 Protein ID WP_000994224.1
Coordinates 3739885..3740160 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3739728..3740150 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN31_RS18550 3735946..3736683 - 738 WP_001535430.1 pili assembly chaperone SafB -
DXN31_RS18555 3736767..3737279 - 513 WP_077248260.1 pilus assembly protein -
DXN31_RS18560 3738029..3738733 - 705 Protein_3637 integrase core domain-containing protein -
DXN31_RS18565 3738786..3739034 + 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN31_RS18570 3739136..3739444 - 309 WP_010988969.1 hypothetical protein -
DXN31_RS18575 3739527..3739643 - 117 WP_227457392.1 hypothetical protein -
- 3739728..3740150 - 423 - - Antitoxin
DXN31_RS18580 3739885..3740160 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
DXN31_RS18585 3740213..3740650 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN31_RS18590 3741213..3741659 - 447 WP_000935097.1 protein SciX -
DXN31_RS18595 3741653..3742522 - 870 Protein_3644 polymorphic toxin type 47 domain-containing protein -
DXN31_RS18600 3742586..3742849 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gtrA / gtrB / gmhA/lpcA 3629211..3749615 120404
flank IS/Tn - - 3738029..3738310 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146528 WP_000994224.1 NZ_CP047540:3739885-3740160 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146528 NZ_CP062758:3582108-3582395 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 423 bp

>AT146528 NZ_CP047540:c3740150-3739728 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References