271202

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3667049..3667481 Replicon chromosome
Accession NZ_CP117404
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM085

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag PQQ07_RS18010 Protein ID WP_000994224.1
Coordinates 3667206..3667481 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3667049..3667471 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ07_RS17980 3663267..3664004 - 738 WP_001535430.1 pili assembly chaperone SafB -
PQQ07_RS17985 3664088..3664600 - 513 WP_077905298.1 pilus assembly protein -
PQQ07_RS17990 3665350..3666054 - 705 Protein_3516 integrase core domain-containing protein -
PQQ07_RS17995 3666107..3666355 + 249 WP_001738030.1 SymE family type I addiction module toxin -
PQQ07_RS18000 3666457..3666765 - 309 WP_010988969.1 hypothetical protein -
PQQ07_RS18005 3666848..3666964 - 117 WP_227457392.1 hypothetical protein -
- 3667049..3667471 - 423 - - Antitoxin
PQQ07_RS18010 3667206..3667481 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
PQQ07_RS18015 3667534..3667971 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
PQQ07_RS18020 3668534..3668980 - 447 WP_000935097.1 protein SciX -
PQQ07_RS18025 3668974..3669842 - 869 Protein_3523 polymorphic toxin type 47 domain-containing protein -
PQQ07_RS18030 3669906..3670169 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3656197..3670169 13972
flank IS/Tn - - 3665350..3665631 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T271202 WP_000994224.1 NZ_CP117404:3667206-3667481 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT271202 NZ_CP117404:c3667471-3667049 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References