270594

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3736523..3736937 Replicon chromosome
Accession NZ_CP117336
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM052

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag PQP91_RS18600 Protein ID WP_000994230.1
Coordinates 3736680..3736937 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3736523..3736855 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP91_RS18560 3731784..3732236 - 453 WP_001675682.1 Saf-pilin pilus formation protein SafA -
PQP91_RS18565 3733045..3733615 - 571 Protein_3635 integrase core domain-containing protein -
PQP91_RS18570 3733536..3733745 - 210 WP_001676010.1 hypothetical protein -
PQP91_RS18575 3733798..3734112 + 315 WP_072100769.1 SymE family type I addiction module toxin -
PQP91_RS18580 3734179..3734457 - 279 WP_012543321.1 hypothetical protein -
PQP91_RS18585 3734773..3735240 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
PQP91_RS18590 3735237..3735554 - 318 WP_001751277.1 hypothetical protein -
PQP91_RS18595 3736112..3736345 - 234 WP_124084119.1 hypothetical protein -
- 3736523..3736855 - 333 - - Antitoxin
PQP91_RS18600 3736680..3736937 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
PQP91_RS18605 3737003..3737449 - 447 WP_000171102.1 hypothetical protein -
PQP91_RS18610 3737446..3740268 - 2823 Protein_3644 RHS repeat-associated core domain-containing protein -
PQP91_RS18615 3740259..3740525 + 267 WP_223151220.1 SymE family type I addiction module toxin -
PQP91_RS18620 3740643..3740981 - 339 WP_000201550.1 hypothetical protein -
PQP91_RS18625 3741003..3741323 - 321 WP_016695071.1 HNH endonuclease -
PQP91_RS18630 3741381..3741664 - 284 Protein_3648 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3723889..3742217 18328
flank IS/Tn - - 3733045..3733323 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T270594 WP_000994230.1 NZ_CP117336:3736680-3736937 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT270594 NZ_CP117336:c3736855-3736523 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References