270637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3734261..3734675 Replicon chromosome
Accession NZ_CP117340
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM111

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag PQQ02_RS18580 Protein ID WP_000994230.1
Coordinates 3734418..3734675 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3734261..3734593 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ02_RS18540 3729522..3729974 - 453 WP_001675682.1 Saf-pilin pilus formation protein SafA -
PQQ02_RS18545 3730783..3731353 - 571 Protein_3631 integrase core domain-containing protein -
PQQ02_RS18550 3731274..3731483 - 210 WP_001676010.1 hypothetical protein -
PQQ02_RS18555 3731536..3731850 + 315 WP_072100769.1 SymE family type I addiction module toxin -
PQQ02_RS18560 3731917..3732195 - 279 WP_012543321.1 hypothetical protein -
PQQ02_RS18565 3732511..3732978 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
PQQ02_RS18570 3732975..3733292 - 318 WP_001751277.1 hypothetical protein -
PQQ02_RS18575 3733850..3734083 - 234 WP_124084119.1 hypothetical protein -
- 3734261..3734593 - 333 - - Antitoxin
PQQ02_RS18580 3734418..3734675 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
PQQ02_RS18585 3734741..3735187 - 447 WP_000171102.1 hypothetical protein -
PQQ02_RS18590 3735184..3738006 - 2823 Protein_3640 RHS repeat-associated core domain-containing protein -
PQQ02_RS18595 3737997..3738263 + 267 WP_223151220.1 SymE family type I addiction module toxin -
PQQ02_RS18600 3738381..3738719 - 339 WP_000201550.1 hypothetical protein -
PQQ02_RS18605 3738741..3739061 - 321 WP_016695071.1 HNH endonuclease -
PQQ02_RS18610 3739119..3739402 - 284 Protein_3644 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3720889..3739955 19066
flank IS/Tn - - 3730783..3731061 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T270637 WP_000994230.1 NZ_CP117340:3734418-3734675 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT270637 NZ_CP117340:c3734593-3734261 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References