221497

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 2436630..2437044 Replicon chromosome
Accession NZ_CP085799
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Swellow

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF54_RS12165 Protein ID WP_000994230.1
Coordinates 2436787..2437044 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 2436630..2436962 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF54_RS12125 2431891..2432388 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LJF54_RS12130 2433151..2433721 - 571 Protein_2373 integrase core domain-containing protein -
LJF54_RS12135 2433642..2433851 - 210 WP_001676010.1 hypothetical protein -
LJF54_RS12140 2433904..2434218 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF54_RS12145 2434285..2434563 - 279 WP_012543321.1 hypothetical protein -
LJF54_RS12150 2434880..2435347 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF54_RS12155 2435344..2435661 - 318 WP_001751277.1 hypothetical protein -
LJF54_RS12160 2436219..2436452 - 234 WP_124084119.1 hypothetical protein -
- 2436630..2436962 - 333 - - Antitoxin
LJF54_RS12165 2436787..2437044 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LJF54_RS12170 2437110..2437556 - 447 WP_000171102.1 hypothetical protein -
LJF54_RS12175 2437553..2440927 - 3375 Protein_2382 RHS domain-containing protein -
LJF54_RS12180 2440927..2441433 - 507 Protein_2383 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2423995..2440849 16854
flank IS/Tn - - 2433151..2433429 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221497 WP_000994230.1 NZ_CP085799:2436787-2437044 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221497 NZ_CP117400:3761315-3761590 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 333 bp

>AT221497 NZ_CP085799:c2436962-2436630 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References