221913

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1548263..1548677 Replicon chromosome
Accession NZ_CP085817
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF67_RS07235 Protein ID WP_000994230.1
Coordinates 1548263..1548520 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1548345..1548677 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF67_RS07220 1543874..1544380 + 507 Protein_1392 phage late control D family protein -
LJF67_RS07225 1544380..1547754 + 3375 Protein_1393 RHS domain-containing protein -
LJF67_RS07230 1547751..1548197 + 447 WP_000171102.1 hypothetical protein -
LJF67_RS07235 1548263..1548520 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 1548345..1548677 + 333 - - Antitoxin
LJF67_RS07240 1548855..1549088 + 234 WP_124084119.1 hypothetical protein -
LJF67_RS07245 1549646..1549963 + 318 WP_001751277.1 hypothetical protein -
LJF67_RS07250 1549960..1550427 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF67_RS07255 1550744..1551022 + 279 WP_012543321.1 hypothetical protein -
LJF67_RS07260 1551089..1551403 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF67_RS07265 1551456..1551665 + 210 WP_001676010.1 hypothetical protein -
LJF67_RS07270 1551586..1552156 + 571 Protein_1402 integrase core domain-containing protein -
LJF67_RS07275 1552919..1553416 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1542959..1562050 19091
flank IS/Tn - - 1551878..1552156 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221913 WP_000994230.1 NZ_CP085817:c1548520-1548263 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221913 NZ_CP117628:c531508-531167 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCACCATTACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTTACCACCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAGAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 333 bp

>AT221913 NZ_CP085817:1548345-1548677 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References