233714

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3636406..3636838 Replicon chromosome
Accession NZ_CP091556
Organism Salmonella enterica strain 632

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag INN80_RS18110 Protein ID WP_000994224.1
Coordinates 3636563..3636838 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3636406..3636828 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN80_RS18080 3632624..3633361 - 738 WP_001535430.1 pili assembly chaperone SafB -
INN80_RS18085 3633445..3633957 - 513 WP_077248260.1 pilus assembly protein -
INN80_RS18090 3634707..3635411 - 705 Protein_3544 integrase core domain-containing protein -
INN80_RS18095 3635464..3635712 + 249 WP_001738030.1 SymE family type I addiction module toxin -
INN80_RS18100 3635814..3636122 - 309 WP_010988969.1 hypothetical protein -
INN80_RS18105 3636205..3636321 - 117 WP_227457392.1 hypothetical protein -
- 3636406..3636828 - 423 - - Antitoxin
INN80_RS18110 3636563..3636838 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
INN80_RS18115 3636891..3637328 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
INN80_RS18120 3637891..3638337 - 447 WP_000935097.1 protein SciX -
INN80_RS18125 3638331..3639200 - 870 Protein_3551 polymorphic toxin type 47 domain-containing protein -
INN80_RS18130 3639264..3639527 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3625554..3639527 13973
flank IS/Tn - - 3634707..3634988 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T233714 WP_000994224.1 NZ_CP091556:3636563-3636838 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T233714 NZ_LN554884:897961-898161 [Staphylococcus xylosus]
GTGCAATCAAAAGTAATTTACGTCTCAGGTATTAATTCAGAACGACAATATCAAATAAAACAACGATTAATGAATGTTAT
AGGTGTACACAGTGTTGCTATAGATAGTGATAAAGGAGAAATACTTGTCGATTTTGAAACACCTGCGAGTTTAAATAATT
TGGAAAAAGAAATTTATGATCTTGGATATCAAATATTTTAA

Antitoxin


Download         Length: 423 bp

>AT233714 NZ_CP091556:c3636828-3636406 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References