221990

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 2854274..2854706 Replicon chromosome
Accession NZ_CP085820
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Wartortle

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag LJF64_RS13475 Protein ID WP_000994224.1
Coordinates 2854274..2854549 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 2854284..2854706 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF64_RS13455 2851585..2851848 + 264 WP_000932531.1 hypothetical protein -
LJF64_RS13460 2851912..2852781 + 870 Protein_2612 polymorphic toxin type 47 domain-containing protein -
LJF64_RS13465 2852775..2853221 + 447 WP_000935097.1 protein SciX -
LJF64_RS13470 2853784..2854221 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
LJF64_RS13475 2854274..2854549 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 2854284..2854706 + 423 - - Antitoxin
LJF64_RS13480 2854734..2854907 + 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
LJF64_RS13485 2854990..2855298 + 309 WP_010988969.1 hypothetical protein -
LJF64_RS13490 2855400..2855648 - 249 WP_001738030.1 SymE family type I addiction module toxin -
LJF64_RS13495 2855701..2856405 + 705 Protein_2619 integrase core domain-containing protein -
LJF64_RS13500 2857155..2857667 + 513 WP_105907557.1 pilus assembly protein -
LJF64_RS13505 2857751..2858488 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2852008..2866296 14288
flank IS/Tn - - 2856124..2856405 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T221990 WP_000994224.1 NZ_CP085820:c2854549-2854274 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T221990 NZ_CP117650:c2076179-2075775 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 423 bp

>AT221990 NZ_CP085820:2854284-2854706 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References