Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
| Location | 1986649..1987081 | Replicon | chromosome |
| Accession | NZ_OU015340 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00027944 isolate AUSMDU00027944 | ||
Toxin (Protein)
| Gene name | IasE | Uniprot ID | E8XIW0 |
| Locus tag | KKR00_RS10375 | Protein ID | WP_000994224.1 |
| Coordinates | 1986806..1987081 (+) | Length | 92 a.a. |
Antitoxin (RNA)
| Gene name | IsrA | ||
| Locus tag | - | ||
| Coordinates | 1986649..1987071 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KKR00_RS10345 | 1982867..1983604 | - | 738 | WP_001535430.1 | pili assembly chaperone SafB | - |
| KKR00_RS10350 | 1983688..1984200 | - | 513 | WP_077248260.1 | pilus assembly protein | - |
| KKR00_RS10355 | 1984950..1985654 | - | 705 | Protein_2042 | integrase core domain-containing protein | - |
| KKR00_RS10360 | 1985707..1985955 | + | 249 | WP_001738030.1 | SymE family type I addiction module toxin | - |
| KKR00_RS10365 | 1986057..1986365 | - | 309 | WP_010988969.1 | hypothetical protein | - |
| KKR00_RS26485 | 1986448..1986564 | - | 117 | WP_227457392.1 | hypothetical protein | - |
| - | 1986649..1987071 | - | 423 | - | - | Antitoxin |
| KKR00_RS10375 | 1986806..1987081 | + | 276 | WP_000994224.1 | SymE family type I addiction module toxin | Toxin |
| KKR00_RS10380 | 1987134..1987571 | - | 438 | WP_000943619.1 | immunity 26/phosphotriesterase HocA family protein | - |
| KKR00_RS10385 | 1988134..1988580 | - | 447 | WP_000935097.1 | protein SciX | - |
| KKR00_RS10390 | 1988574..1989443 | - | 870 | Protein_2049 | polymorphic toxin type 47 domain-containing protein | - |
| KKR00_RS10395 | 1989507..1989770 | - | 264 | WP_000932531.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | - | 1975797..1989770 | 13973 | ||
| flank | IS/Tn | - | - | 1984950..1985231 | 281 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10032.36 Da Isoelectric Point: 6.4704
>T294637 WP_000994224.1 NZ_OU015340:1986806-1987081 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
Download Length: 276 bp
Antitoxin
Download Length: 423 bp
>AT294637 NZ_OU015340:c1987071-1986649 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
