270855

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3855699..3856113 Replicon chromosome
Accession NZ_CP117367
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM079

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag PQQ12_RS19170 Protein ID WP_000994230.1
Coordinates 3855856..3856113 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3855699..3856031 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ12_RS19130 3850960..3851412 - 453 WP_001675682.1 Saf-pilin pilus formation protein SafA -
PQQ12_RS19135 3852221..3852791 - 571 Protein_3751 integrase core domain-containing protein -
PQQ12_RS19140 3852712..3852921 - 210 WP_001676010.1 hypothetical protein -
PQQ12_RS19145 3852974..3853288 + 315 WP_072100769.1 SymE family type I addiction module toxin -
PQQ12_RS19150 3853355..3853633 - 279 WP_012543321.1 hypothetical protein -
PQQ12_RS19155 3853949..3854416 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
PQQ12_RS19160 3854413..3854730 - 318 WP_001751277.1 hypothetical protein -
PQQ12_RS19165 3855288..3855521 - 234 WP_124084119.1 hypothetical protein -
- 3855699..3856031 - 333 - - Antitoxin
PQQ12_RS19170 3855856..3856113 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
PQQ12_RS19175 3856179..3856625 - 447 WP_000171102.1 hypothetical protein -
PQQ12_RS19180 3856622..3859444 - 2823 Protein_3760 RHS repeat-associated core domain-containing protein -
PQQ12_RS19185 3859435..3859701 + 267 WP_223151220.1 SymE family type I addiction module toxin -
PQQ12_RS19190 3859819..3860157 - 339 WP_000201550.1 hypothetical protein -
PQQ12_RS19195 3860179..3860499 - 321 WP_016695071.1 HNH endonuclease -
PQQ12_RS19200 3860557..3860840 - 284 Protein_3764 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3843065..3861393 18328
flank IS/Tn - - 3852221..3852499 278
- inside Genomic island - - 3843065..3860372 17307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T270855 WP_000994230.1 NZ_CP117367:3855856-3856113 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT270855 NZ_CP117367:c3856031-3855699 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References