270042

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 994657..995089 Replicon chromosome
Accession NZ_CP117184
Organism Salmonella enterica subsp. enterica strain 123

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag PQ453_RS04700 Protein ID WP_000994224.1
Coordinates 994657..994932 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 994667..995089 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ453_RS04680 991968..992231 + 264 WP_000932531.1 hypothetical protein -
PQ453_RS04685 992295..993164 + 870 Protein_908 polymorphic toxin type 47 domain-containing protein -
PQ453_RS04690 993158..993604 + 447 WP_000935097.1 protein SciX -
PQ453_RS04695 994167..994604 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
PQ453_RS04700 994657..994932 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 994667..995089 + 423 - - Antitoxin
PQ453_RS04705 995174..995290 + 117 WP_227457392.1 hypothetical protein -
PQ453_RS04710 995373..995681 + 309 WP_010988969.1 hypothetical protein -
PQ453_RS04715 995783..996031 - 249 WP_001738030.1 SymE family type I addiction module toxin -
PQ453_RS04720 996084..996788 + 705 Protein_915 integrase core domain-containing protein -
PQ453_RS04725 997538..998050 + 513 WP_077248260.1 pilus assembly protein -
PQ453_RS04730 998134..998871 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 992391..1006679 14288
flank IS/Tn - - 996507..996788 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T270042 WP_000994224.1 NZ_CP117184:c994932-994657 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT270042 NZ_CP117184:994667-995089 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References