221523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 2436600..2437014 Replicon chromosome
Accession NZ_CP085800
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Taillow

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF53_RS12160 Protein ID WP_000994230.1
Coordinates 2436757..2437014 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 2436600..2436932 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF53_RS12120 2431861..2432358 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LJF53_RS12125 2433121..2433691 - 571 Protein_2372 integrase core domain-containing protein -
LJF53_RS12130 2433612..2433821 - 210 WP_001676010.1 hypothetical protein -
LJF53_RS12135 2433874..2434188 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF53_RS12140 2434255..2434533 - 279 WP_012543321.1 hypothetical protein -
LJF53_RS12145 2434850..2435317 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF53_RS12150 2435314..2435631 - 318 WP_001751277.1 hypothetical protein -
LJF53_RS12155 2436189..2436422 - 234 WP_124084119.1 hypothetical protein -
- 2436600..2436932 - 333 - - Antitoxin
LJF53_RS12160 2436757..2437014 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LJF53_RS12165 2437080..2437526 - 447 WP_000171102.1 hypothetical protein -
LJF53_RS12170 2437523..2440897 - 3375 Protein_2381 RHS domain-containing protein -
LJF53_RS12175 2440897..2441403 - 507 Protein_2382 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2423965..2440819 16854
flank IS/Tn - - 2433121..2433399 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221523 WP_000994230.1 NZ_CP085800:2436757-2437014 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221523 NZ_CP117404:3667206-3667481 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 333 bp

>AT221523 NZ_CP085800:c2436932-2436600 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References