203040

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3595841..3596255 Replicon chromosome
Accession NZ_CP075120
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051882

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag BCB01_RS17585 Protein ID WP_000994230.1
Coordinates 3595998..3596255 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3595841..3596173 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB01_RS17545 3591102..3591599 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
BCB01_RS17550 3592362..3592932 - 571 Protein_3446 integrase core domain-containing protein -
BCB01_RS17555 3592853..3593062 - 210 WP_001676010.1 hypothetical protein -
BCB01_RS17560 3593115..3593429 + 315 WP_072100769.1 SymE family type I addiction module toxin -
BCB01_RS17565 3593496..3593774 - 279 WP_012543321.1 hypothetical protein -
BCB01_RS17570 3594091..3594558 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
BCB01_RS17575 3594555..3594872 - 318 WP_001751277.1 hypothetical protein -
BCB01_RS17580 3595430..3595663 - 234 WP_124084119.1 hypothetical protein -
- 3595841..3596173 - 333 - - Antitoxin
BCB01_RS17585 3595998..3596255 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
BCB01_RS17590 3596374..3596766 - 393 WP_001720247.1 hypothetical protein -
BCB01_RS17595 3596763..3600137 - 3375 Protein_3455 RHS domain-containing protein -
BCB01_RS17600 3600137..3600643 - 507 Protein_3456 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3583206..3596766 13560
flank IS/Tn - - 3592362..3592640 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T203040 WP_000994230.1 NZ_CP075120:3595998-3596255 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T203040 NZ_CP099868:1923697-1924029 [Escherichia albertii]
ATGGACAGAGGAGAAATCTGGCTTGTTTCACTTGACCCTATCGCCGGGCATGAGCAAAGCGGAAAACGCCCGGTGCTTAT
CGTTTCTCCGGCCTCGTTTAACGAGGTCACCCGGTTGCCCGTCATTGTTCCGGTAACCAGCGGTGGGCAATTTGCCCGTA
GCGCGGGTTTTGCGGTTTCGCTGGAGGGCGCTGGCACAAAAACGACGGGGATTATTCGTTGCGATCAGCCCAGAACCATT
GATATGGGAGCCCGAAACGGTAAGCGGCTGGAGCGCATACCTGACGGTATCATCAACGAGGTGCTGGCAAGGCTGGAAAC
CATCCTGGCCTGA

Antitoxin


Download         Length: 333 bp

>AT203040 NZ_CP075120:c3596173-3595841 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References