221336

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 932381..932795 Replicon chromosome
Accession NZ_CP085793
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF61_RS04305 Protein ID WP_000994230.1
Coordinates 932381..932638 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 932463..932795 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF61_RS04290 927992..928498 + 507 Protein_822 phage late control D family protein -
LJF61_RS04295 928498..931872 + 3375 Protein_823 RHS domain-containing protein -
LJF61_RS04300 931869..932315 + 447 WP_000171102.1 hypothetical protein -
LJF61_RS04305 932381..932638 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 932463..932795 + 333 - - Antitoxin
LJF61_RS04310 932973..933206 + 234 WP_124084119.1 hypothetical protein -
LJF61_RS04315 933764..934081 + 318 WP_001751277.1 hypothetical protein -
LJF61_RS04320 934078..934545 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF61_RS04325 934862..935140 + 279 WP_012543321.1 hypothetical protein -
LJF61_RS04330 935207..935521 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF61_RS04335 935574..935783 + 210 WP_001676010.1 hypothetical protein -
LJF61_RS04340 935704..936274 + 571 Protein_832 integrase core domain-containing protein -
LJF61_RS04345 937037..937534 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 927077..946168 19091
flank IS/Tn - - 935996..936274 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221336 WP_000994230.1 NZ_CP085793:c932638-932381 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221336 NZ_CP117378:c4644963-4644652 [Salmonella enterica subsp. enterica serovar Newport]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 333 bp

>AT221336 NZ_CP085793:932463-932795 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References