Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3744371..3744803 Replicon chromosome
Accession NZ_CP091540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag L5Z03_RS18640 Protein ID WP_000994224.1
Coordinates 3744528..3744803 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3744371..3744793 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z03_RS18610 3740589..3741326 - 738 WP_001535430.1 pili assembly chaperone SafB -
L5Z03_RS18615 3741410..3741922 - 513 WP_077248260.1 pilus assembly protein -
L5Z03_RS18620 3742672..3743376 - 705 Protein_3645 integrase core domain-containing protein -
L5Z03_RS18625 3743429..3743677 + 249 WP_001738030.1 SymE family type I addiction module toxin -
L5Z03_RS18630 3743779..3744087 - 309 WP_010988969.1 hypothetical protein -
L5Z03_RS18635 3744170..3744286 - 117 WP_227457392.1 hypothetical protein -
- 3744371..3744793 - 423 - - Antitoxin
L5Z03_RS18640 3744528..3744803 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
L5Z03_RS18645 3744856..3745293 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
L5Z03_RS18650 3745856..3746302 - 447 WP_000935097.1 protein SciX -
L5Z03_RS18655 3746296..3747165 - 870 Protein_3652 polymorphic toxin type 47 domain-containing protein -
L5Z03_RS18660 3747229..3747492 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3733519..3747492 13973
flank IS/Tn - - 3742672..3742953 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T233587 WP_000994224.1 NZ_CP091540:3744528-3744803 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T233587 NZ_HG994850:c4400177-4399800 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 423 bp

>AT233587 NZ_CP091540:c3744793-3744371 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References