275524

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3602026..3602440 Replicon chromosome
Accession NZ_CP121003
Organism Salmonella enterica strain 31A

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag P6590_RS17735 Protein ID WP_000994230.1
Coordinates 3602183..3602440 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3602026..3602358 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6590_RS17695 3597287..3597784 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
P6590_RS17700 3598547..3599117 - 571 Protein_3461 integrase core domain-containing protein -
P6590_RS17705 3599038..3599247 - 210 WP_001676010.1 hypothetical protein -
P6590_RS17710 3599300..3599614 + 315 WP_072100769.1 SymE family type I addiction module toxin -
P6590_RS17715 3599681..3599959 - 279 WP_012543321.1 hypothetical protein -
P6590_RS17720 3600276..3600743 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
P6590_RS17725 3600740..3601057 - 318 WP_001751277.1 hypothetical protein -
P6590_RS17730 3601615..3601848 - 234 WP_124084119.1 hypothetical protein -
- 3602026..3602358 - 333 - - Antitoxin
P6590_RS17735 3602183..3602440 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
P6590_RS17740 3602506..3602952 - 447 WP_000171102.1 hypothetical protein -
P6590_RS17745 3602949..3606323 - 3375 Protein_3470 RHS repeat-associated core domain-containing protein -
P6590_RS17750 3606323..3606829 - 507 Protein_3471 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3591718..3606233 14515
flank IS/Tn - - 3598547..3598825 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T275524 WP_000994230.1 NZ_CP121003:3602183-3602440 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT275524 NZ_CP121003:c3602358-3602026 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References