258773

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3987367..3987781 Replicon chromosome
Accession NZ_CP104643
Organism Salmonella enterica strain 1020677

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag N5930_RS19665 Protein ID WP_000994230.1
Coordinates 3987524..3987781 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3987367..3987699 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5930_RS19625 3982628..3983125 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
N5930_RS19630 3983888..3984458 - 571 Protein_3818 integrase core domain-containing protein -
N5930_RS19635 3984379..3984588 - 210 WP_001676010.1 hypothetical protein -
N5930_RS19640 3984641..3984955 + 315 WP_072100769.1 SymE family type I addiction module toxin -
N5930_RS19645 3985022..3985300 - 279 WP_012543321.1 hypothetical protein -
N5930_RS19650 3985617..3986084 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
N5930_RS19655 3986081..3986398 - 318 WP_001751277.1 hypothetical protein -
N5930_RS19660 3986956..3987189 - 234 WP_124084119.1 hypothetical protein -
- 3987367..3987699 - 333 - - Antitoxin
N5930_RS19665 3987524..3987781 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
N5930_RS19670 3987847..3988293 - 447 WP_000171102.1 hypothetical protein -
N5930_RS19675 3988290..3991664 - 3375 Protein_3827 RHS domain-containing protein -
N5930_RS19680 3991664..3992170 - 507 Protein_3828 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3974733..3991586 16853
flank IS/Tn - - 3983888..3984166 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T258773 WP_000994230.1 NZ_CP104643:3987524-3987781 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT258773 NZ_CP104643:c3987699-3987367 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References