37233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3724842..3725274 Replicon chromosome
Accession NZ_AP023290
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3844

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag K5615_RS18425 Protein ID WP_000994224.1
Coordinates 3724999..3725274 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3724842..3725264 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5615_RS18395 3721060..3721797 - 738 WP_001535430.1 pili assembly chaperone SafB -
K5615_RS18400 3721881..3722393 - 513 WP_077248260.1 pilus assembly protein -
K5615_RS18405 3723143..3723847 - 705 Protein_3617 integrase core domain-containing protein -
K5615_RS18410 3723900..3724148 + 249 WP_001738030.1 SymE family type I addiction module toxin -
K5615_RS18415 3724250..3724558 - 309 WP_010988969.1 hypothetical protein -
K5615_RS18420 3724641..3724814 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3724842..3725264 - 423 - - Antitoxin
K5615_RS18425 3724999..3725274 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
K5615_RS18430 3725327..3725764 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
K5615_RS18435 3726327..3726773 - 447 WP_000935097.1 protein SciX -
K5615_RS18440 3726767..3727636 - 870 Protein_3624 polymorphic toxin type 47 domain-containing protein -
K5615_RS18445 3727700..3727963 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3716314..3727963 11649
flank IS/Tn - - 3723143..3723424 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T37233 WP_000994224.1 NZ_AP023290:3724999-3725274 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T37233 NZ_AP023290:3724999-3725274 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT37233 NZ_AP023290:c3725264-3724842 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References