231083

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3723171..3723603 Replicon chromosome
Accession NZ_CP090535
Organism Salmonella enterica strain 2016089-SE

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag L0F58_RS18395 Protein ID WP_000994224.1
Coordinates 3723328..3723603 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3723171..3723593 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F58_RS18365 3719389..3720126 - 738 WP_001535430.1 pili assembly chaperone SafB -
L0F58_RS18370 3720210..3720722 - 513 WP_077248260.1 pilus assembly protein -
L0F58_RS18375 3721472..3722176 - 705 Protein_3599 integrase core domain-containing protein -
L0F58_RS18380 3722229..3722477 + 249 WP_001738030.1 SymE family type I addiction module toxin -
L0F58_RS18385 3722579..3722887 - 309 WP_010988969.1 hypothetical protein -
L0F58_RS18390 3722970..3723086 - 117 WP_227457392.1 hypothetical protein -
- 3723171..3723593 - 423 - - Antitoxin
L0F58_RS18395 3723328..3723603 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
L0F58_RS18400 3723656..3724093 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
L0F58_RS18405 3724656..3725102 - 447 WP_000935097.1 protein SciX -
L0F58_RS18410 3725096..3725965 - 870 Protein_3606 polymorphic toxin type 47 domain-containing protein -
L0F58_RS18415 3726029..3726292 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3712319..3726292 13973
flank IS/Tn - - 3721472..3721753 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T231083 WP_000994224.1 NZ_CP090535:3723328-3723603 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T231083 NZ_CP125957:216477-216659 [Pseudomonas sp. G2-4]
ATGCGAAGTCGGGAAATGATCAGGAAGATCGAGGAAGACGGTTGGTACCTTGTGGCAGTAAGGGGAAGCCATCATCAATA
CAAACACGCCTTCAAGGCGGGAAGGGTGACGATCAAGCACCCTGACTCGGACCTGCCAAAAGGCACCATTAACAGCATAT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 423 bp

>AT231083 NZ_CP090535:c3723593-3723171 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References