146617

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1232158..1232590 Replicon chromosome
Accession NZ_CP047548
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10169

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN26_RS05755 Protein ID WP_000994224.1
Coordinates 1232158..1232433 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1232168..1232590 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN26_RS05735 1229469..1229732 + 264 WP_000932531.1 hypothetical protein -
DXN26_RS05740 1229796..1230665 + 870 Protein_1104 polymorphic toxin type 47 domain-containing protein -
DXN26_RS05745 1230659..1231105 + 447 WP_000935097.1 protein SciX -
DXN26_RS05750 1231668..1232105 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN26_RS05755 1232158..1232433 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 1232168..1232590 + 423 - - Antitoxin
DXN26_RS05760 1232675..1232791 + 117 WP_227457392.1 hypothetical protein -
DXN26_RS05765 1232874..1233182 + 309 WP_010988969.1 hypothetical protein -
DXN26_RS05770 1233284..1233532 - 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN26_RS05775 1233585..1234289 + 705 Protein_1111 integrase core domain-containing protein -
DXN26_RS05780 1235039..1235551 + 513 WP_077248260.1 pilus assembly protein -
DXN26_RS05785 1235635..1236372 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1229892..1244180 14288
flank IS/Tn - - 1234008..1234289 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146617 WP_000994224.1 NZ_CP047548:c1232433-1232158 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146617 NZ_CP062766:3634548-3634835 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 423 bp

>AT146617 NZ_CP047548:1232168-1232590 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References