258750

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3635422..3635836 Replicon chromosome
Accession NZ_CP104641
Organism Salmonella enterica strain 1019942

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag N5927_RS17980 Protein ID WP_000994230.1
Coordinates 3635579..3635836 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3635422..3635754 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5927_RS17940 3630683..3631180 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
N5927_RS17945 3631943..3632513 - 571 Protein_3508 integrase core domain-containing protein -
N5927_RS17950 3632434..3632643 - 210 WP_001676010.1 hypothetical protein -
N5927_RS17955 3632696..3633010 + 315 WP_072100769.1 SymE family type I addiction module toxin -
N5927_RS17960 3633077..3633355 - 279 WP_012543321.1 hypothetical protein -
N5927_RS17965 3633672..3634139 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
N5927_RS17970 3634136..3634453 - 318 WP_001751277.1 hypothetical protein -
N5927_RS17975 3635011..3635244 - 234 WP_124084119.1 hypothetical protein -
- 3635422..3635754 - 333 - - Antitoxin
N5927_RS17980 3635579..3635836 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
N5927_RS17985 3635902..3636348 - 447 WP_000171102.1 hypothetical protein -
N5927_RS17990 3636345..3639719 - 3375 Protein_3517 RHS domain-containing protein -
N5927_RS17995 3639719..3640225 - 507 Protein_3518 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3625115..3639641 14526
flank IS/Tn - - 3631943..3632221 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T258750 WP_000994230.1 NZ_CP104641:3635579-3635836 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT258750 NZ_CP104641:c3635754-3635422 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References