Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 2400238..2400670 Replicon chromosome
Accession NZ_CP047555
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN18_RS11415 Protein ID WP_000994224.1
Coordinates 2400238..2400513 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 2400248..2400670 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN18_RS11395 2397549..2397812 + 264 WP_000932531.1 hypothetical protein -
DXN18_RS11400 2397876..2398745 + 870 Protein_2217 polymorphic toxin type 47 domain-containing protein -
DXN18_RS11405 2398739..2399185 + 447 WP_000935097.1 protein SciX -
DXN18_RS11410 2399748..2400185 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN18_RS11415 2400238..2400513 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 2400248..2400670 + 423 - - Antitoxin
DXN18_RS11420 2400755..2400871 + 117 WP_227457392.1 hypothetical protein -
DXN18_RS11425 2400954..2401262 + 309 WP_010988969.1 hypothetical protein -
DXN18_RS11430 2401364..2401612 - 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN18_RS11435 2401665..2402369 + 705 Protein_2224 integrase core domain-containing protein -
DXN18_RS11440 2403119..2403631 + 513 WP_077248260.1 pilus assembly protein -
DXN18_RS11445 2403715..2404452 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2397972..2412260 14288
flank IS/Tn - - 2402088..2402369 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146698 WP_000994224.1 NZ_CP047555:c2400513-2400238 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146698 NZ_CP062774:c2259425-2259147 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 423 bp

>AT146698 NZ_CP047555:2400248-2400670 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References