146653

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3764529..3764961 Replicon chromosome
Accession NZ_CP047550
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10057

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN07_RS18705 Protein ID WP_000994224.1
Coordinates 3764686..3764961 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3764529..3764951 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN07_RS18675 3760747..3761484 - 738 WP_001535430.1 pili assembly chaperone SafB -
DXN07_RS18680 3761568..3762080 - 513 WP_077248260.1 pilus assembly protein -
DXN07_RS18685 3762830..3763534 - 705 Protein_3662 integrase core domain-containing protein -
DXN07_RS18690 3763587..3763835 + 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN07_RS18695 3763937..3764245 - 309 WP_010988969.1 hypothetical protein -
DXN07_RS18700 3764328..3764501 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3764529..3764951 - 423 - - Antitoxin
DXN07_RS18705 3764686..3764961 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
DXN07_RS18710 3765014..3765451 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN07_RS18715 3766014..3766460 - 447 WP_000935097.1 protein SciX -
DXN07_RS18720 3766454..3767323 - 870 Protein_3669 polymorphic toxin type 47 domain-containing protein -
DXN07_RS18725 3767387..3767650 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3762830..3763111 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146653 WP_000994224.1 NZ_CP047550:3764686-3764961 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146653 NZ_CP062769:c4999168-4998995 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 423 bp

>AT146653 NZ_CP047550:c3764951-3764529 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References