Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
| Location | 886272..886686 | Replicon | chromosome |
| Accession | NZ_CP100666 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630 | ||
Toxin (Protein)
| Gene name | IasE | Uniprot ID | M7RBD3 |
| Locus tag | NL709_RS04140 | Protein ID | WP_000994230.1 |
| Coordinates | 886272..886529 (-) | Length | 86 a.a. |
Antitoxin (RNA)
| Gene name | IsrA | ||
| Locus tag | - | ||
| Coordinates | 886354..886686 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NL709_RS04125 | 881883..882389 | + | 507 | Protein_796 | phage late control D family protein | - |
| NL709_RS04130 | 882389..885763 | + | 3375 | Protein_797 | RHS domain-containing protein | - |
| NL709_RS04135 | 885760..886206 | + | 447 | WP_000171102.1 | hypothetical protein | - |
| NL709_RS04140 | 886272..886529 | - | 258 | WP_000994230.1 | SymE family type I addiction module toxin | Toxin |
| - | 886354..886686 | + | 333 | - | - | Antitoxin |
| NL709_RS04145 | 886864..887097 | + | 234 | WP_124084119.1 | hypothetical protein | - |
| NL709_RS04150 | 887655..887972 | + | 318 | WP_001751277.1 | hypothetical protein | - |
| NL709_RS04155 | 887969..888436 | + | 468 | WP_000828182.1 | sugar tyrosine-protein kinase | - |
| NL709_RS04160 | 888753..889031 | + | 279 | WP_012543321.1 | hypothetical protein | - |
| NL709_RS04165 | 889098..889412 | - | 315 | WP_072100769.1 | SymE family type I addiction module toxin | - |
| NL709_RS04170 | 889465..889674 | + | 210 | WP_001676010.1 | hypothetical protein | - |
| NL709_RS04175 | 889595..890165 | + | 571 | Protein_806 | integrase core domain-containing protein | - |
| NL709_RS04180 | 890928..891425 | + | 498 | WP_016695185.1 | Saf-pilin pilus formation protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 880968..900059 | 19091 | |
| flank | IS/Tn | - | - | 889887..890165 | 278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9490.94 Da Isoelectric Point: 9.5519
>T250924 WP_000994230.1 NZ_CP100666:c886529-886272 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
Download Length: 258 bp
Antitoxin
Download Length: 333 bp
>AT250924 NZ_CP100666:886354-886686 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
