252125

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3784744..3785176 Replicon chromosome
Accession NZ_CP101390
Organism Salmonella enterica strain SC2017297

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NMU39_RS18790 Protein ID WP_000994224.1
Coordinates 3784901..3785176 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3784744..3785166 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU39_RS18760 3780962..3781699 - 738 WP_001535430.1 pili assembly chaperone SafB -
NMU39_RS18765 3781783..3782295 - 513 WP_077248260.1 pilus assembly protein -
NMU39_RS18770 3783045..3783749 - 705 Protein_3673 integrase core domain-containing protein -
NMU39_RS18775 3783802..3784050 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NMU39_RS18780 3784152..3784460 - 309 WP_010988969.1 hypothetical protein -
NMU39_RS18785 3784543..3784659 - 117 WP_227457392.1 hypothetical protein -
- 3784744..3785166 - 423 - - Antitoxin
NMU39_RS18790 3784901..3785176 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NMU39_RS18795 3785229..3785666 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NMU39_RS18800 3786229..3786675 - 447 WP_000935097.1 protein SciX -
NMU39_RS18805 3786669..3787538 - 870 Protein_3680 polymorphic toxin type 47 domain-containing protein -
NMU39_RS18810 3787602..3787865 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3773892..3787865 13973
flank IS/Tn - - 3783045..3783326 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T252125 WP_000994224.1 NZ_CP101390:3784901-3785176 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT252125 NZ_CP101390:c3785166-3784744 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References