202580

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3716316..3716748 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag BG493_RS18235 Protein ID WP_000994224.1
Coordinates 3716473..3716748 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3716316..3716738 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS18205 3712534..3713271 - 738 WP_001535430.1 pili assembly chaperone SafB -
BG493_RS18210 3713355..3713867 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
BG493_RS18215 3714617..3715321 - 705 Protein_3578 integrase core domain-containing protein -
BG493_RS18220 3715374..3715622 + 249 WP_001738030.1 SymE family type I addiction module toxin -
BG493_RS18225 3715724..3716032 - 309 WP_010988969.1 hypothetical protein -
BG493_RS24275 3716115..3716231 - 117 WP_227457392.1 hypothetical protein -
- 3716316..3716738 - 423 - - Antitoxin
BG493_RS18235 3716473..3716748 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
BG493_RS18240 3716801..3717238 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
BG493_RS18245 3717801..3718247 - 447 WP_000935097.1 protein SciX -
BG493_RS18250 3718241..3719110 - 870 Protein_3585 polymorphic toxin type 47 domain-containing protein -
BG493_RS18255 3719174..3719437 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3705464..3719437 13973
flank IS/Tn - - 3714617..3714898 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T202580 WP_000994224.1 NZ_CP074663:3716473-3716748 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T202580 NZ_CP074663:3716473-3716748 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT202580 NZ_CP074663:c3716738-3716316 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References