Detailed information of TA system TA203525

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3766223..3766655
• Replicon: chromosome
• Accession: NZ_CP075372
• Organism: Salmonella enterica strain no75

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: KH432_RS18590
• Protein ID: WP_000994224.1
• Coordinates: 3766380..3766655 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3766223..3766645 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KH432_RS18560	3762441..3763178	-	738	WP_001535430.1	pili assembly chaperone SafB	-
KH432_RS18565	3763262..3763774	-	513	WP_077248260.1	pilus assembly protein	-
KH432_RS18570	3764524..3765228	-	705	Protein_3658	integrase core domain-containing protein	-
KH432_RS18575	3765281..3765529	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
KH432_RS18580	3765631..3765939	-	309	WP_010988969.1	hypothetical protein	-
KH432_RS26275	3766022..3766195	-	174	WP_088131292.1	RHS repeat-associated core domain-containing protein	-
-	3766223..3766645	-	423	-	-	Antitoxin
KH432_RS18590	3766380..3766655	+	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
KH432_RS18595	3766708..3767145	-	438	WP_000943619.1	immunity 26/phosphotriesterase HocA family protein	-
KH432_RS18600	3767708..3768154	-	447	WP_000935097.1	protein SciX	-
KH432_RS18605	3768148..3769017	-	870	Protein_3665	polymorphic toxin type 47 domain-containing protein	-
KH432_RS18610	3769081..3769344	-	264	WP_000932531.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 Genomic island TA010103 336540..350828 0.002 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S Genomic island TA026042 337747..352035 0.002	inside	Genomic island	-	-	3755371..3769344	13973
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003197 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 IS/Tn TA010105 341179..341460 0 View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA010103 340656..340937 0 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026042 341863..342144 0	flank	IS/Tn	-	-	3764524..3764805	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T203525 WP_000994224.1 NZ_CP075372:3766380-3766655 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

>T203525 NZ_CP100110:c5014046-5013129 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCATCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 423 bp

>AT203525 NZ_CP075372:c3766645-3766223 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin