222077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3831332..3831746 Replicon chromosome
Accession NZ_CP085823
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Venusaur

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF47_RS18575 Protein ID WP_000994230.1
Coordinates 3831332..3831589 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3831414..3831746 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF47_RS18560 3826943..3827449 + 507 Protein_3610 phage late control D family protein -
LJF47_RS18565 3827449..3830823 + 3375 Protein_3611 RHS domain-containing protein -
LJF47_RS18570 3830820..3831266 + 447 WP_000171102.1 hypothetical protein -
LJF47_RS18575 3831332..3831589 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 3831414..3831746 + 333 - - Antitoxin
LJF47_RS18580 3831924..3832157 + 234 WP_124084119.1 hypothetical protein -
LJF47_RS18585 3832715..3833032 + 318 WP_001751277.1 hypothetical protein -
LJF47_RS18590 3833029..3833496 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF47_RS18595 3833813..3834091 + 279 WP_012543321.1 hypothetical protein -
LJF47_RS18600 3834158..3834472 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF47_RS18605 3834525..3834734 + 210 WP_001676010.1 hypothetical protein -
LJF47_RS18610 3834655..3835225 + 571 Protein_3620 integrase core domain-containing protein -
LJF47_RS18615 3835988..3836485 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3826028..3845119 19091
flank IS/Tn - - 3834947..3835225 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T222077 WP_000994230.1 NZ_CP085823:c3831589-3831332 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T222077 NZ_CP117672:3549769-3549987 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 333 bp

>AT222077 NZ_CP085823:3831414-3831746 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References