231134

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3730818..3731250 Replicon chromosome
Accession NZ_CP090541
Organism Salmonella enterica strain 2010112-SE

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag L0F62_RS18520 Protein ID WP_000994224.1
Coordinates 3730975..3731250 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3730818..3731240 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F62_RS18490 3727036..3727773 - 738 WP_001535430.1 pili assembly chaperone SafB -
L0F62_RS18495 3727857..3728369 - 513 WP_077248260.1 pilus assembly protein -
L0F62_RS18500 3729119..3729823 - 705 Protein_3620 integrase core domain-containing protein -
L0F62_RS18505 3729876..3730124 + 249 WP_001738030.1 SymE family type I addiction module toxin -
L0F62_RS18510 3730226..3730534 - 309 WP_010988969.1 hypothetical protein -
L0F62_RS18515 3730617..3730733 - 117 WP_227457392.1 hypothetical protein -
- 3730818..3731240 - 423 - - Antitoxin
L0F62_RS18520 3730975..3731250 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
L0F62_RS18525 3731303..3731740 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
L0F62_RS18530 3732303..3732749 - 447 WP_000935097.1 protein SciX -
L0F62_RS18535 3732743..3733612 - 870 Protein_3627 polymorphic toxin type 47 domain-containing protein -
L0F62_RS18540 3733676..3733939 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3719966..3733939 13973
flank IS/Tn - - 3729119..3729400 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T231134 WP_000994224.1 NZ_CP090541:3730975-3731250 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T231134 NZ_CP126063:72284-72700 [Klebsiella pneumoniae subsp. pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCTGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 423 bp

>AT231134 NZ_CP090541:c3731240-3730818 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References