226804

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3744757..3745189 Replicon chromosome
Accession NZ_CP088138
Organism Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag LRM92_RS18580 Protein ID WP_000994224.1
Coordinates 3744914..3745189 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3744757..3745179 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM92_RS18550 3740975..3741712 - 738 WP_001535430.1 pili assembly chaperone SafB -
LRM92_RS18555 3741796..3742308 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
LRM92_RS18560 3743058..3743762 - 705 Protein_3637 integrase core domain-containing protein -
LRM92_RS18565 3743815..3744063 + 249 WP_001738030.1 SymE family type I addiction module toxin -
LRM92_RS18570 3744165..3744473 - 309 WP_010988969.1 hypothetical protein -
LRM92_RS18575 3744556..3744672 - 117 WP_227457392.1 hypothetical protein -
- 3744757..3745179 - 423 - - Antitoxin
LRM92_RS18580 3744914..3745189 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
LRM92_RS18585 3745242..3745679 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
LRM92_RS18590 3746242..3746688 - 447 WP_000935097.1 protein SciX -
LRM92_RS18595 3746682..3747551 - 870 Protein_3644 polymorphic toxin type 47 domain-containing protein -
LRM92_RS18600 3747615..3747878 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3733905..3747878 13973
flank IS/Tn - - 3743058..3743339 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T226804 WP_000994224.1 NZ_CP088138:3744914-3745189 [Salmonella enterica subsp. enterica serovar Hissar]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T226804 NZ_CP122629:2803817-2803924 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 423 bp

>AT226804 NZ_CP088138:c3745179-3744757 [Salmonella enterica subsp. enterica serovar Hissar]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References