269891

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3763153..3763585 Replicon chromosome
Accession NZ_CP117033
Organism Salmonella enterica strain PIW95_S14_0299

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag PQP07_RS18755 Protein ID WP_000994224.1
Coordinates 3763310..3763585 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3763153..3763575 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP07_RS18725 3759371..3760108 - 738 WP_001535430.1 pili assembly chaperone SafB -
PQP07_RS18730 3760192..3760704 - 513 WP_077248260.1 pilus assembly protein -
PQP07_RS18735 3761454..3762158 - 705 Protein_3667 integrase core domain-containing protein -
PQP07_RS18740 3762211..3762459 + 249 WP_001738030.1 SymE family type I addiction module toxin -
PQP07_RS18745 3762561..3762869 - 309 WP_010988969.1 hypothetical protein -
PQP07_RS18750 3762952..3763068 - 117 WP_227457392.1 hypothetical protein -
- 3763153..3763575 - 423 - - Antitoxin
PQP07_RS18755 3763310..3763585 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
PQP07_RS18760 3763638..3764075 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
PQP07_RS18765 3764638..3765084 - 447 WP_000935097.1 protein SciX -
PQP07_RS18770 3765078..3765947 - 870 Protein_3674 polymorphic toxin type 47 domain-containing protein -
PQP07_RS18775 3766011..3766274 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3752301..3766274 13973
flank IS/Tn - - 3761454..3761735 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T269891 WP_000994224.1 NZ_CP117033:3763310-3763585 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT269891 NZ_CP117033:c3763575-3763153 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References