Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3637434..3637866 Replicon chromosome
Accession NZ_CP100732
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.1932

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NL737_RS17865 Protein ID WP_000994224.1
Coordinates 3637591..3637866 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3637434..3637856 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL737_RS17835 3633652..3634389 - 738 WP_001535430.1 pili assembly chaperone SafB -
NL737_RS17840 3634473..3634985 - 513 WP_077248260.1 pilus assembly protein -
NL737_RS17845 3635735..3636439 - 705 Protein_3487 integrase core domain-containing protein -
NL737_RS17850 3636492..3636740 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NL737_RS17855 3636842..3637150 - 309 WP_010988969.1 hypothetical protein -
NL737_RS17860 3637233..3637349 - 117 WP_227457392.1 hypothetical protein -
- 3637434..3637856 - 423 - - Antitoxin
NL737_RS17865 3637591..3637866 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NL737_RS17870 3637919..3638356 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NL737_RS17875 3638919..3639365 - 447 WP_000935097.1 protein SciX -
NL737_RS17880 3639359..3640228 - 870 Protein_3494 polymorphic toxin type 47 domain-containing protein -
NL737_RS17885 3640292..3640555 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3628906..3640555 11649
flank IS/Tn - - 3635735..3636016 281
- inside Prophage - gmhA/lpcA 3526213..3647321 121108


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T251269 WP_000994224.1 NZ_CP100732:3637591-3637866 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT251269 NZ_CP100732:c3637856-3637434 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References