Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
Location | 3637434..3637866 | Replicon | chromosome |
Accession | NZ_CP100732 | ||
Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain R18.1932 |
Toxin (Protein)
Gene name | IasE | Uniprot ID | E8XIW0 |
Locus tag | NL737_RS17865 | Protein ID | WP_000994224.1 |
Coordinates | 3637591..3637866 (+) | Length | 92 a.a. |
Antitoxin (RNA)
Gene name | IsrA | ||
Locus tag | - | ||
Coordinates | 3637434..3637856 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NL737_RS17835 | 3633652..3634389 | - | 738 | WP_001535430.1 | pili assembly chaperone SafB | - |
NL737_RS17840 | 3634473..3634985 | - | 513 | WP_077248260.1 | pilus assembly protein | - |
NL737_RS17845 | 3635735..3636439 | - | 705 | Protein_3487 | integrase core domain-containing protein | - |
NL737_RS17850 | 3636492..3636740 | + | 249 | WP_001738030.1 | SymE family type I addiction module toxin | - |
NL737_RS17855 | 3636842..3637150 | - | 309 | WP_010988969.1 | hypothetical protein | - |
NL737_RS17860 | 3637233..3637349 | - | 117 | WP_227457392.1 | hypothetical protein | - |
- | 3637434..3637856 | - | 423 | - | - | Antitoxin |
NL737_RS17865 | 3637591..3637866 | + | 276 | WP_000994224.1 | SymE family type I addiction module toxin | Toxin |
NL737_RS17870 | 3637919..3638356 | - | 438 | WP_000943619.1 | immunity 26/phosphotriesterase HocA family protein | - |
NL737_RS17875 | 3638919..3639365 | - | 447 | WP_000935097.1 | protein SciX | - |
NL737_RS17880 | 3639359..3640228 | - | 870 | Protein_3494 | polymorphic toxin type 47 domain-containing protein | - |
NL737_RS17885 | 3640292..3640555 | - | 264 | WP_000932531.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 3628906..3640555 | 11649 | ||
flank | IS/Tn | - | - | 3635735..3636016 | 281 | ||
- | inside | Prophage | - | gmhA/lpcA | 3526213..3647321 | 121108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10032.36 Da Isoelectric Point: 6.4704
>T251269 WP_000994224.1 NZ_CP100732:3637591-3637866 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
Download Length: 276 bp
Antitoxin
Download Length: 423 bp
>AT251269 NZ_CP100732:c3637856-3637434 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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