203187

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3699769..3700183 Replicon chromosome
Accession NZ_CP075134
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain CFSAN044909

Toxin (Protein)


Gene name IasE Uniprot ID A0A5Y7XEW6
Locus tag A7S31_RS18220 Protein ID WP_000994226.1
Coordinates 3699926..3700183 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3699769..3700101 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S31_RS18190 3695243..3695983 - 741 WP_043986360.1 pili assembly chaperone SafB -
A7S31_RS18195 3696063..3696560 - 498 WP_070810897.1 Saf-pilin pilus formation protein SafA -
A7S31_RS18200 3696693..3697187 - 495 WP_070793507.1 hypothetical protein -
A7S31_RS18205 3698073..3698774 - 702 Protein_3586 integrase core domain-containing protein -
A7S31_RS18210 3698827..3699141 + 315 WP_023892102.1 SymE family type I addiction module toxin -
A7S31_RS18215 3699208..3699486 - 279 WP_012664366.1 hypothetical protein -
- 3699769..3700101 - 333 - - Antitoxin
A7S31_RS18220 3699926..3700183 + 258 WP_000994226.1 SymE family type I addiction module toxin Toxin
A7S31_RS18225 3700274..3700651 - 378 WP_000739708.1 Imm8 family immunity protein -
A7S31_RS18230 3700971..3701132 - 162 WP_001658759.1 RHS repeat-associated core domain-containing protein -
A7S31_RS18235 3701305..3701643 - 339 WP_000357802.1 hypothetical protein -
A7S31_RS18240 3701910..3702221 - 312 WP_001220174.1 hypothetical protein -
A7S31_RS18245 3702241..3703176 - 936 Protein_3594 RHS domain-containing protein -
A7S31_RS18250 3703194..3703622 - 429 Protein_3595 DUF1795 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3688166..3702221 14055
flank IS/Tn - - 3698073..3698351 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9547.82 Da        Isoelectric Point: 5.0770

>T203187 WP_000994226.1 NZ_CP075134:3699926-3700183 [Salmonella enterica subsp. enterica serovar Saintpaul]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGRSVTVKISQECIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Download         Length: 258 bp

>T203187 NZ_CP099890:c2438095-2437631 [Escherichia albertii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAACCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTTTCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACACTGCGCACCTACGGTAAAAAAACAGATGCCTATACAGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCAAGAGACAGAAGAAAAGCATTGA

Antitoxin


Download         Length: 333 bp

>AT203187 NZ_CP075134:c3700101-3699769 [Salmonella enterica subsp. enterica serovar Saintpaul]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y7XEW6

Antitoxin

Download structure file

References