Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3711991..3712423 Replicon chromosome
Accession NZ_CP117357
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM096

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag PQQ15_RS18340 Protein ID WP_000994224.1
Coordinates 3712148..3712423 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3711991..3712413 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ15_RS18310 3708209..3708946 - 738 WP_001535430.1 pili assembly chaperone SafB -
PQQ15_RS18315 3709030..3709542 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
PQQ15_RS18320 3710292..3710996 - 705 Protein_3583 integrase core domain-containing protein -
PQQ15_RS18325 3711049..3711297 + 249 WP_001738030.1 SymE family type I addiction module toxin -
PQQ15_RS18330 3711399..3711707 - 309 WP_010988969.1 hypothetical protein -
PQQ15_RS18335 3711790..3711906 - 117 WP_227457392.1 hypothetical protein -
- 3711991..3712413 - 423 - - Antitoxin
PQQ15_RS18340 3712148..3712423 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
PQQ15_RS18345 3712476..3712913 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
PQQ15_RS18350 3713476..3713922 - 447 WP_000935097.1 protein SciX -
PQQ15_RS18355 3713916..3714263 - 348 WP_274882531.1 polymorphic toxin type 47 domain-containing protein -
PQQ15_RS18360 3714251..3714783 - 533 Protein_3591 RHS repeat-associated core domain-containing protein -
PQQ15_RS18365 3714847..3715110 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3701139..3715110 13971
flank IS/Tn - - 3710292..3710573 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T270774 WP_000994224.1 NZ_CP117357:3712148-3712423 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT270774 NZ_CP117357:c3712413-3711991 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References