221394

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 2248337..2248751 Replicon chromosome
Accession NZ_CP085795
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Frogadier

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF59_RS10600 Protein ID WP_000994230.1
Coordinates 2248337..2248594 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 2248419..2248751 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF59_RS10585 2243948..2244454 + 507 Protein_2041 phage late control D family protein -
LJF59_RS10590 2244454..2247828 + 3375 Protein_2042 RHS domain-containing protein -
LJF59_RS10595 2247825..2248271 + 447 WP_000171102.1 hypothetical protein -
LJF59_RS10600 2248337..2248594 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 2248419..2248751 + 333 - - Antitoxin
LJF59_RS10605 2248929..2249162 + 234 WP_124084119.1 hypothetical protein -
LJF59_RS10610 2249720..2250037 + 318 WP_001751277.1 hypothetical protein -
LJF59_RS10615 2250034..2250501 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF59_RS10620 2250818..2251096 + 279 WP_012543321.1 hypothetical protein -
LJF59_RS10625 2251163..2251477 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF59_RS10630 2251530..2251739 + 210 WP_001676010.1 hypothetical protein -
LJF59_RS10635 2251660..2252230 + 571 Protein_2051 integrase core domain-containing protein -
LJF59_RS10640 2252993..2253490 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2242734..2260328 17594
flank IS/Tn - - 2251952..2252230 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221394 WP_000994230.1 NZ_CP085795:c2248594-2248337 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221394 NZ_CP117386:c4308885-4308394 [Salmonella enterica subsp. enterica serovar Uganda]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 333 bp

>AT221394 NZ_CP085795:2248419-2248751 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References