233614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3744243..3744675 Replicon chromosome
Accession NZ_CP091542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag L5Z53_RS18645 Protein ID WP_000994224.1
Coordinates 3744400..3744675 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3744243..3744665 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z53_RS18615 3740461..3741198 - 738 WP_001535430.1 pili assembly chaperone SafB -
L5Z53_RS18620 3741282..3741794 - 513 WP_077248260.1 pilus assembly protein -
L5Z53_RS18625 3742544..3743248 - 705 Protein_3645 integrase core domain-containing protein -
L5Z53_RS18630 3743301..3743549 + 249 WP_001738030.1 SymE family type I addiction module toxin -
L5Z53_RS18635 3743651..3743959 - 309 WP_010988969.1 hypothetical protein -
L5Z53_RS18640 3744042..3744158 - 117 WP_227457392.1 hypothetical protein -
- 3744243..3744665 - 423 - - Antitoxin
L5Z53_RS18645 3744400..3744675 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
L5Z53_RS18650 3744728..3745165 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
L5Z53_RS18655 3745728..3746174 - 447 WP_000935097.1 protein SciX -
L5Z53_RS18660 3746168..3747037 - 870 Protein_3652 polymorphic toxin type 47 domain-containing protein -
L5Z53_RS18665 3747101..3747364 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3733391..3747364 13973
flank IS/Tn - - 3742544..3742825 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T233614 WP_000994224.1 NZ_CP091542:3744400-3744675 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T233614 NZ_HG995459:c1689252-1688677 [Pseudomonas sp. PP3]
GTGAGGCACTCCGCTTTTACCGCTGTATATGACGCTTGCGTGCTTTACCCTGCGCCCTTGAGAGACTTTCTTATTTGGCT
TGCGCTCTCCGGTCGGTTTCGGGCGAAATGGTCGATGGAGATACACAACGAATGGAAACGCAATCTGCTGAAAAACCGAC
CGGACCTGACGATAGAGCAACTGAATCGAACATCTGAACTGATGGATGTGGCCGTTCCAGATGCATGTGTCAAAGGTTAT
GAAGAACTGATTGCAGGACTTACGCTACCCGATGCCGATGACCGACATGTTCTGGCGGCCGCCATCCGCTGCGACGCGAG
CGTTATCGTCACGTTCAATCGCAAAGATTTTCCCTGCTCGGCTTTGGGAGTTTATGACATCGAAGCCCAGCACCCCGATG
AGTTCGTTAGCAACCTCTTTGACCTGGATCCCGCCGCAGTGGTCTCTGCGGCTCAACGCCAACGAAAACAGCTGAAGATG
CCGCCCATGGATATCAGCACTTACCTCGACCTTATGTTTCGACAAGGTTTGGTTCAGTCAGCCAAAGCGCTGAACGATTA
CCGAACGATGCTTTAA

Antitoxin


Download         Length: 423 bp

>AT233614 NZ_CP091542:c3744665-3744243 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References