146487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1233845..1234277 Replicon chromosome
Accession NZ_CP047537
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10405

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN32_RS05765 Protein ID WP_000994224.1
Coordinates 1233845..1234120 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1233855..1234277 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN32_RS05745 1231156..1231419 + 264 WP_000932531.1 hypothetical protein -
DXN32_RS05750 1231483..1232352 + 870 Protein_1106 polymorphic toxin type 47 domain-containing protein -
DXN32_RS05755 1232346..1232792 + 447 WP_000935097.1 protein SciX -
DXN32_RS05760 1233355..1233792 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN32_RS05765 1233845..1234120 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 1233855..1234277 + 423 - - Antitoxin
DXN32_RS05770 1234362..1234478 + 117 WP_227457392.1 hypothetical protein -
DXN32_RS05775 1234561..1234869 + 309 WP_010988969.1 hypothetical protein -
DXN32_RS05780 1234971..1235219 - 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN32_RS05785 1235272..1235976 + 705 Protein_1113 integrase core domain-containing protein -
DXN32_RS05790 1236726..1237238 + 513 WP_077248260.1 pilus assembly protein -
DXN32_RS05795 1237322..1238059 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1231579..1245867 14288
flank IS/Tn - - 1235695..1235976 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146487 WP_000994224.1 NZ_CP047537:c1234120-1233845 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146487 NZ_CP062755:751358-751672 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 423 bp

>AT146487 NZ_CP047537:1233855-1234277 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References