215565

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1187300..1187714 Replicon chromosome
Accession NZ_CP082916
Organism Salmonella enterica subsp. enterica serovar Newlands strain ZC-S1 3rd

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag K8862_RS06000 Protein ID WP_000994230.1
Coordinates 1187457..1187714 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1187300..1187632 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8862_RS05960 1182561..1183058 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
K8862_RS05965 1183821..1184391 - 571 Protein_1163 integrase core domain-containing protein -
K8862_RS05970 1184312..1184521 - 210 WP_001676010.1 hypothetical protein -
K8862_RS05975 1184574..1184888 + 315 WP_072100769.1 SymE family type I addiction module toxin -
K8862_RS05980 1184955..1185233 - 279 WP_012543321.1 hypothetical protein -
K8862_RS05985 1185550..1186017 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
K8862_RS05990 1186014..1186331 - 318 WP_001751277.1 hypothetical protein -
K8862_RS05995 1186889..1187122 - 234 WP_124084119.1 hypothetical protein -
- 1187300..1187632 - 333 - - Antitoxin
K8862_RS06000 1187457..1187714 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
K8862_RS06005 1187780..1188226 - 447 WP_000171102.1 hypothetical protein -
K8862_RS06010 1188223..1191597 - 3375 Protein_1172 RHS domain-containing protein -
K8862_RS06015 1191597..1192103 - 507 Protein_1173 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1176992..1191519 14527
flank IS/Tn - - 1183821..1184099 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T215565 WP_000994230.1 NZ_CP082916:1187457-1187714 [Salmonella enterica subsp. enterica serovar Newlands]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T215565 NZ_CP110815:c66960-66544 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 333 bp

>AT215565 NZ_CP082916:c1187632-1187300 [Salmonella enterica subsp. enterica serovar Newlands]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References