222100

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3953760..3954174 Replicon chromosome
Accession NZ_CP085824
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Ivysaur

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF36_RS19410 Protein ID WP_000994230.1
Coordinates 3953917..3954174 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3953760..3954092 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF36_RS19370 3949021..3949518 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LJF36_RS19375 3950281..3950851 - 571 Protein_3769 integrase core domain-containing protein -
LJF36_RS19380 3950772..3950981 - 210 WP_001676010.1 hypothetical protein -
LJF36_RS19385 3951034..3951348 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF36_RS19390 3951415..3951693 - 279 WP_012543321.1 hypothetical protein -
LJF36_RS19395 3952010..3952477 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF36_RS19400 3952474..3952791 - 318 WP_001751277.1 hypothetical protein -
LJF36_RS19405 3953349..3953582 - 234 WP_124084119.1 hypothetical protein -
- 3953760..3954092 - 333 - - Antitoxin
LJF36_RS19410 3953917..3954174 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LJF36_RS19415 3954240..3954686 - 447 WP_000171102.1 hypothetical protein -
LJF36_RS19420 3954683..3958057 - 3375 Protein_3778 RHS domain-containing protein -
LJF36_RS19425 3958057..3958563 - 507 Protein_3779 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3943452..3957979 14527
flank IS/Tn - - 3950281..3950559 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T222100 WP_000994230.1 NZ_CP085824:3953917-3954174 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T222100 NZ_CP117693:219867-220352 [Salmonella enterica subsp. enterica serovar London]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTCGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTACAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGAGCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCAAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 333 bp

>AT222100 NZ_CP085824:c3954092-3953760 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References