Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 2042544..2042976 Replicon chromosome
Accession NZ_CP085987
Organism Salmonella enterica strain SZL 38

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag LKX03_RS10860 Protein ID WP_000994224.1
Coordinates 2042701..2042976 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 2042544..2042966 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKX03_RS10830 2038762..2039499 - 738 WP_001535430.1 pili assembly chaperone SafB -
LKX03_RS10835 2039583..2040095 - 513 WP_077248260.1 pilus assembly protein -
LKX03_RS10840 2040845..2041549 - 705 Protein_2041 integrase core domain-containing protein -
LKX03_RS10845 2041602..2041850 + 249 WP_001738030.1 SymE family type I addiction module toxin -
LKX03_RS10850 2041952..2042260 - 309 WP_010988969.1 hypothetical protein -
LKX03_RS10855 2042343..2042459 - 117 WP_227457392.1 hypothetical protein -
- 2042544..2042966 - 423 - - Antitoxin
LKX03_RS10860 2042701..2042976 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
LKX03_RS10865 2043029..2043466 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
LKX03_RS10870 2044029..2044475 - 447 WP_000935097.1 protein SciX -
LKX03_RS10875 2044469..2045338 - 870 Protein_2048 polymorphic toxin type 47 domain-containing protein -
LKX03_RS10880 2045402..2045665 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2031692..2045665 13973
flank IS/Tn - - 2040845..2041126 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T222415 WP_000994224.1 NZ_CP085987:2042701-2042976 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T222415 NZ_CP117851:c1688802-1688491 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGTTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCCTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 423 bp

>AT222415 NZ_CP085987:c2042966-2042544 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References