Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 4182862..4183294 Replicon chromosome
Accession NZ_CP068696
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP16345

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag JKV46_RS20720 Protein ID WP_000994224.1
Coordinates 4183019..4183294 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 4182862..4183284 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV46_RS20690 4179080..4179817 - 738 WP_001535430.1 pili assembly chaperone SafB -
JKV46_RS20695 4179901..4180413 - 513 WP_105907557.1 pilus assembly protein -
JKV46_RS20700 4181163..4181867 - 705 Protein_4036 integrase core domain-containing protein -
JKV46_RS20705 4181920..4182168 + 249 WP_001738030.1 SymE family type I addiction module toxin -
JKV46_RS20710 4182270..4182578 - 309 WP_010988969.1 hypothetical protein -
JKV46_RS20715 4182661..4182777 - 117 WP_227457392.1 hypothetical protein -
- 4182862..4183284 - 423 - - Antitoxin
JKV46_RS20720 4183019..4183294 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
JKV46_RS20725 4183347..4183784 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
JKV46_RS20730 4184347..4184793 - 447 WP_000935097.1 protein SciX -
JKV46_RS20735 4184787..4185656 - 870 Protein_4043 polymorphic toxin type 47 domain-containing protein -
JKV46_RS20740 4185720..4185983 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4172010..4185983 13973
flank IS/Tn - - 4181163..4181444 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T187615 WP_000994224.1 NZ_CP068696:4183019-4183294 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T187615 NZ_CP089927:c2726330-2725938 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 423 bp

>AT187615 NZ_CP068696:c4183284-4182862 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References