282686

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3601607..3602021 Replicon chromosome
Accession NZ_CP126140
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain DSE06

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag QNM21_RS17720 Protein ID WP_000994230.1
Coordinates 3601764..3602021 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3601607..3601939 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM21_RS17680 3596868..3597365 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
QNM21_RS17685 3598128..3598698 - 571 Protein_3461 integrase core domain-containing protein -
QNM21_RS17690 3598619..3598828 - 210 WP_001676010.1 hypothetical protein -
QNM21_RS17695 3598881..3599195 + 315 WP_072100769.1 SymE family type I addiction module toxin -
QNM21_RS17700 3599262..3599540 - 279 WP_012543321.1 hypothetical protein -
QNM21_RS17705 3599857..3600324 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
QNM21_RS17710 3600321..3600638 - 318 WP_001751277.1 hypothetical protein -
QNM21_RS17715 3601196..3601429 - 234 WP_124084119.1 hypothetical protein -
- 3601607..3601939 - 333 - - Antitoxin
QNM21_RS17720 3601764..3602021 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
QNM21_RS17725 3602087..3602533 - 447 WP_000171102.1 hypothetical protein -
QNM21_RS17730 3602530..3605904 - 3375 Protein_3470 RHS repeat-associated core domain-containing protein -
QNM21_RS17735 3605904..3606410 - 507 Protein_3471 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3591299..3605826 14527
flank IS/Tn - - 3598128..3598406 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-56)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T282686 WP_000994230.1 NZ_CP126140:3601764-3602021 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp


Antitoxin


Download         Length: 333 bp

>AT282686 NZ_CP126140:c3601939-3601607 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A656IER2


Antitoxin

Download structure file

References