Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
Location | 3602035..3602449 | Replicon | chromosome |
Accession | NZ_CP122301 | ||
Organism | Salmonella enterica strain 27A |
Toxin (Protein)
Gene name | IasE | Uniprot ID | M7RBD3 |
Locus tag | P8R57_RS17730 | Protein ID | WP_000994230.1 |
Coordinates | 3602192..3602449 (+) | Length | 86 a.a. |
Antitoxin (RNA)
Gene name | IsrA | ||
Locus tag | - | ||
Coordinates | 3602035..3602367 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P8R57_RS17690 | 3597296..3597793 | - | 498 | WP_016695185.1 | Saf-pilin pilus formation protein | - |
P8R57_RS17695 | 3598556..3599126 | - | 571 | Protein_3460 | integrase core domain-containing protein | - |
P8R57_RS17700 | 3599047..3599256 | - | 210 | WP_001676010.1 | hypothetical protein | - |
P8R57_RS17705 | 3599309..3599623 | + | 315 | WP_072100769.1 | SymE family type I addiction module toxin | - |
P8R57_RS17710 | 3599690..3599968 | - | 279 | WP_012543321.1 | hypothetical protein | - |
P8R57_RS17715 | 3600285..3600752 | - | 468 | WP_000828182.1 | sugar tyrosine-protein kinase | - |
P8R57_RS17720 | 3600749..3601066 | - | 318 | WP_001751277.1 | hypothetical protein | - |
P8R57_RS17725 | 3601624..3601857 | - | 234 | WP_124084119.1 | hypothetical protein | - |
- | 3602035..3602367 | - | 333 | - | - | Antitoxin |
P8R57_RS17730 | 3602192..3602449 | + | 258 | WP_000994230.1 | SymE family type I addiction module toxin | Toxin |
P8R57_RS17735 | 3602515..3602961 | - | 447 | WP_000171102.1 | hypothetical protein | - |
P8R57_RS17740 | 3602958..3606332 | - | 3375 | Protein_3469 | RHS repeat-associated core domain-containing protein | - |
P8R57_RS17745 | 3606332..3606838 | - | 507 | Protein_3470 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 3591729..3606242 | 14513 | |
flank | IS/Tn | - | - | 3598556..3598834 | 278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9490.94 Da Isoelectric Point: 9.5519
>T276614 WP_000994230.1 NZ_CP122301:3602192-3602449 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
Download Length: 258 bp
Antitoxin
Download Length: 333 bp
>AT276614 NZ_CP122301:c3602367-3602035 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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