Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3602035..3602449 Replicon chromosome
Accession NZ_CP122301
Organism Salmonella enterica strain 27A

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag P8R57_RS17730 Protein ID WP_000994230.1
Coordinates 3602192..3602449 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3602035..3602367 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R57_RS17690 3597296..3597793 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
P8R57_RS17695 3598556..3599126 - 571 Protein_3460 integrase core domain-containing protein -
P8R57_RS17700 3599047..3599256 - 210 WP_001676010.1 hypothetical protein -
P8R57_RS17705 3599309..3599623 + 315 WP_072100769.1 SymE family type I addiction module toxin -
P8R57_RS17710 3599690..3599968 - 279 WP_012543321.1 hypothetical protein -
P8R57_RS17715 3600285..3600752 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
P8R57_RS17720 3600749..3601066 - 318 WP_001751277.1 hypothetical protein -
P8R57_RS17725 3601624..3601857 - 234 WP_124084119.1 hypothetical protein -
- 3602035..3602367 - 333 - - Antitoxin
P8R57_RS17730 3602192..3602449 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
P8R57_RS17735 3602515..3602961 - 447 WP_000171102.1 hypothetical protein -
P8R57_RS17740 3602958..3606332 - 3375 Protein_3469 RHS repeat-associated core domain-containing protein -
P8R57_RS17745 3606332..3606838 - 507 Protein_3470 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3591729..3606242 14513
flank IS/Tn - - 3598556..3598834 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T276614 WP_000994230.1 NZ_CP122301:3602192-3602449 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT276614 NZ_CP122301:c3602367-3602035 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References